Iris Fry’s comments

— On Q01: An important philosophical question which, I believe, should be connected to the role of natural selection in the origin of life. An interesting remark: S. J. Gould, the inventor of “contingency”, states in his Wonderful Life, p. 289, that he considers the origin of life to be “inevitable”.

— On Q03: A crucial empirical question, obviously connected to the specific local in which life might have emerged. Wachtershauser’s experiments are in the right direction.

— On Q04: This question, combined with no. 6 on the RNA world, is actually the issue of metabolism versus replication. The ideas of Orgel on these questions – his support of geneticism versus metabolism, his realization of the difficulties involved in an RNA world scenario, his attempts to find much simpler genetic systems (even oligopeptides) – are worthwhile exploring. All this discussion should be conducted in the context of the role of natural selection in the origin of life

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